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Skull Base Osteomyelitis Complicating COVID-19: A Novel Secondary Infection?
Emel Tahir1, Heval Can Bilek2, Emre Demirel1
1Department of Otorhinolaryngology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Türkiye.
Journal of Clinical Practice and Research
|November 19, 2025
Summary
COVID-19 can lead to severe ear infections like skull base osteomyelitis in immunocompromised patients. Early imaging is crucial for persistent ear discharge after COVID-19 to ensure timely diagnosis and treatment.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Critical Care Medicine
Background:
- The Coronavirus Disease 2019 (COVID-19) pandemic has increased the incidence of secondary infections, including sinonasal mucormycosis and skull base osteomyelitis, particularly in immunocompromised individuals.
- COVID-19-related immunosuppression and treatments can exacerbate comorbidities like diabetes and chronic renal failure, increasing susceptibility to severe infections.
- Angiotensin-Converting Enzyme 2 (ACE2) receptors in the external auditory canal may play a role in COVID-19-associated external otitis.
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