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Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model.

Yudai Goto^1,2,3, Kouji Masumoto¹, Takato Sasaki¹

¹Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Gastroenterology Research and Practice

|November 19, 2025

Summary

Following ileal resection in mice, the colon adapted to maintain bile acid absorption. This adaptation involved increased ASBT expression, suggesting a protective mechanism against impaired absorption in short bowel syndrome.

Keywords:

bile acid absorption colonic adaptation functional adaptation intestinal adaptation short bowel syndrome

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Area of Science:

Gastroenterology
Physiology
Surgical Research

Background:

Short bowel syndrome (SBS) prognosis is influenced by small intestine and colon adaptation.
Ileal resection can lead to malabsorption, impacting nutrient and bile acid homeostasis.
Understanding colonic adaptation is crucial for managing SBS outcomes.

Purpose of the Study:

To investigate colonic adaptation in a mouse model of ileal resection.
To specifically examine the role of bile acid absorption in this adaptation.
To assess changes in gene expression and bile acid concentrations post-ileal resection.

Main Methods:

Created an ileal resection mouse model by resecting 50% of the ileum.
Utilized a sham surgery group for control comparison.
Assessed body weight, colonic histology, bile acid transporter gene expression (Asbt, Fabp6, Ostb, Fxr), and fecal/serum bile acid levels.

Main Results:

Ileal resection mice showed less body weight change and longer colon length compared to sham mice.
No significant histological differences were found in colonic mucosal height.
Increased Asbt (bile acid uptake transporter) expression was observed in the ileal resection group, while fecal and serum bile acid concentrations remained unchanged.

Conclusions:

The colon demonstrates adaptive changes following ileal resection to preserve bile acid absorption.
Increased Asbt expression suggests a compensatory mechanism within the colon.
These findings highlight the colon's role in mitigating the effects of significant small bowel resection.