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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Probiotics Supplementation in Tuberculosis: A Scoping Review.

Tejaswini Baral1, Mohan K Manu2, Kavitha Saravu3

  • 1Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Scientifica
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Summary
This summary is machine-generated.

Probiotics show promise as an add-on therapy for tuberculosis (TB) patients, potentially reducing side effects during intensive treatment. Further research is needed to confirm long-term benefits.

Keywords:
antitubercular therapyprobioticstuberculosis

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Area of Science:

  • Microbiology
  • Clinical Medicine
  • Pharmacology

Background:

  • Tuberculosis (TB) treatment involves intensive antitubercular therapy (ATT) which can cause adverse drug reactions.
  • Gut microbiota dysbiosis is increasingly recognized in TB patients.
  • Probiotics, live microorganisms conferring a health benefit, are being explored for their therapeutic potential in various conditions.

Purpose of the Study:

  • To conduct a scoping review of current clinical evidence on the use of probiotics as an adjunct therapy in tuberculosis (TB).
  • To synthesize findings regarding the efficacy and safety of probiotics during TB treatment.
  • To identify gaps in the existing research.

Main Methods:

  • Systematic literature searches were performed in PubMed, Scopus, and Embase.
  • Studies published between 2016 and 2023 involving probiotics in TB patients were included.
  • A total of six studies met the inclusion criteria for this review.

Main Results:

  • Probiotics were supplemented during the intensive phase of ATT, for durations of 3–8 weeks.
  • Five of the six studies focused on pulmonary TB.
  • Probiotics demonstrated potential in alleviating gastrointestinal and hepatic adverse drug reactions, modulating gut microbiota, enhancing barrier function, and influencing immune responses.

Conclusions:

  • Probiotics represent a potential adjunct therapy during the intensive phase of ATT for TB.
  • Observed benefits include mitigation of drug-induced side effects and modulation of host responses.
  • Long-term effects and sustained benefits of probiotics in TB require further investigation through well-designed longitudinal studies.