Substituted Carboxyamido-propanyl Compounds as Inhibitors of hRSV and hMPV to Treat Viral Respiratory Infections
1Arrival Discovery LLC, San Diego, California 92128, United States.
ACS Medicinal Chemistry Letters
|November 19, 2025
Abstract:
A series of carboxyamido-propanyl analogs is described as antiviral agents for inhibition of the replication of hRSV and hMPV. Human Respiratory Syncytial Virus (hRSV, RSV) belongs to the family Paramyxoviridae and the subfamily Pneumovirinae that are significant human and animal pathogens. After hRSV, hMPV (metapneumovirus) is the second most common cause of lower respiratory infection in young children. Therefore, inhibition of hRSV and hMPV is an important approach for the potential treatment of respiratory viral infections.
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