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Evaluation of the Relationship Between Histopathological Findings in Appendectomy Specimens and Enterobius
Selahattin Aydemir1, Meryem Gümüş1, Merve İnceman2
1Department of Parasitology, Van Yüzüncü Yıl University Faculty of Medicine, Van, Türkiye.
Objective:
This study aimed to assess the relationship between Enterobius vermicularis and appendicitis by determining the frequency of E. vermicularis in appendectomy specimens obtained after a preliminary diagnosis of appendicitis.
Materials And Methods:
Retrospective evaluation was conducted on the results of appendectomy specimens examined histopathologically at Van Training and Research Hospital Pathology Laboratory from March 2016 to March 2022. Hematoxylin-eosin stained slides from 7,814 appendectomy specimens were scrutinized for the presence of E. vermicularis, acute inflammation, fecaloid material, lymphoid hyperplasia, obliteration, perforation, phlegmonous appendicitis, and peritonitis. Furthermore, slides stained with hematoxylin-eosin (H&E) from patients testing positive for E. vermicularis were re-evaluated by the author in pathology.
Results:
E. vermicularis was identified in the appendectomy specimens of 50 (0.64%) out of 7,814 patients who underwent appendectomies. In histopathological examinations, the occurrence of lymphoid hyperplasia and fibrous obliteration was higher in E. vermicularis-positive patients compared to those who teste negative. Findings revealed that the mean white blood cell count (WBC) was lower in E. vermicularis-positive patients than in negative patients, while the mean eosinophil percentage (EO%) was higher.
Conclusion:
These findings imply that although the parasite is not a direct causative factor for appendicitis, it may contribute to the development of factors that result in obstruction in certain cases.
Insights
Enterobius vermicularis (pinworm) was found in 0.64% of appendectomy specimens. While not a direct cause, the parasite may contribute to appendicitis obstruction in some cases.
Area of Science:
- Medical Parasitology
- Gastrointestinal Pathology
- Surgical Pathology
Background:
- Appendicitis is a common surgical emergency.
- The role of Enterobius vermicularis (pinworm) in appendicitis pathogenesis is not fully understood.
- Pinworm infections are prevalent globally, particularly in children.
Purpose of the Study:
- To determine the frequency of Enterobius vermicularis in appendectomy specimens.
- To investigate the association between E. vermicularis and histopathological findings in appendicitis.
- To explore the potential contribution of E. vermicularis to appendicitis development.
Main Methods:
- Retrospective analysis of 7,814 appendectomy specimens from March 2016 to March 2022.
- Histopathological examination using Hematoxylin-eosin staining to identify E. vermicularis, inflammation, and other features.
- Re-evaluation of E. vermicularis-positive slides by the author.
Main Results:
- Enterobius vermicularis was identified in 50 (0.64%) of the 7,814 appendectomy specimens.
- Lymphoid hyperplasia and fibrous obliteration were more frequent in E. vermicularis-positive cases.
- Mean white blood cell count was lower, and mean eosinophil percentage was higher in E. vermicularis-positive patients.
Conclusions:
- Enterobius vermicularis is infrequently found in appendectomy specimens.
- The parasite is unlikely to be a direct cause of appendicitis.
- E. vermicularis may play a role in appendiceal obstruction, contributing to appendicitis in select cases.
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