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Comparison of Glycemic and Anthropometric Parameters Among Patients With Dyspepsia and Dyslipidemia With or Without
Maria Aparecida A Serra1, Mateus D Torres1, Pedro R Rolins Neto1
1Postgraduate Program in Health and Technology, Federal University of Maranhao, Imperatriz, BRA.
Background/Purpose:
This study aimed to compare glycemic and anthropometric parameters among patients with dyspepsia and dyslipidemia, with or without Helicobacter pylori (H. pylori) infection.
Methods:
This was a cross-sectional study of 103 patients referred for upper gastrointestinal endoscopy (UGE) at a public service city of Imperatriz, state of Maranhão, in Northeastern Brazil. Data collection included structured interviews to collect socioeconomic information, anthropometric assessments, and laboratory tests. Participants were categorized as follows: Group 1: dyslipidemia; Group 2: H. pylori infection without dyslipidemia; Group 3: dyslipidemia and H. pylori infection; Group 4: neither (control). Triglyceride-glucose (TyG) index, fasting blood glucose, glycated hemoglobin (HbA1c), and anthropometric parameters were compared across all groups. Statistical comparisons used ANOVA or Kruskal-Wallis with appropriate post-hoc tests; significance threshold p<0.05.
Results:
The TyG index differed significantly across groups (median (range)): Group 1: 9.10 (8.56-11.5), Group 2: 8.18 (7.60-8.84), Group 3: 8.85 (8.18-9.59), Group 4: 8.30 (7.32-10.0; p<0.001). Body mass index (BMI; kg/m²) and waist circumference (WC; cm) were highest in Group 3 (BMI median 30.2 kg/m2; WC mean 106 ± standard deviation (SD) 18.3 cm) (p=0.007 and p<0.001, respectively). No significant differences were observed for HbA1c or fasting glucose.
Conclusion:
Dyslipidemia in dyspeptic patients without H. pylori infection was associated with higher TyG indices; coexisting dyslipidemia and H. pylori infection were associated with increased BMI and WC. No significant differences were observed for HbA1c or fasting glucose between the groups, although the TyG index varied markedly, reflecting discrete changes in insulin sensitivity. These results support integrated screening for dyslipidemia and H. pylori in dyspeptic patients to reduce cardiometabolic risk and gastrointestinal diseases.
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