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Clinical Importance of P Wave Dispersion in Mitral Valve Prolapse

Can Ramazan Öncel1, Cemal Köseoğlu1, Ali Çoner1

  • 1Department of Cardiology, Alanya Alaaddin Keykubat University, Faculty of Medicine, Antalya, Türkiye.

Journal of Clinical Practice and Research
|November 19, 2025
PubMed
Abstract

Insights

Classic mitral valve prolapse (MVP) is linked to higher P wave dispersion (PWD), indicating potential autonomic dysfunction and increased risk of atrial arrhythmias in these patients.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Mitral valve prolapse (MVP) affects 2-6% of the global population, impacting over 170 million individuals.
  • Cardiovascular autonomic dysfunction and atrial arrhythmias are potential complications in MVP patients.

Purpose of the Study:

  • To evaluate P wave dispersion (PWD) in patients with MVP.
  • To identify links between PWD, cardiovascular autonomic dysfunction, and atrial arrhythmia risk in MVP.

Main Methods:

  • The study involved 40 healthy controls, 41 non-classic MVP patients, and 36 classic MVP patients.
  • Electrocardiographic assessment was used to measure PWD in all participants.

Main Results:

  • Classic MVP patients showed significantly lower minimum P wave duration compared to controls and non-classic MVP patients.
  • P wave dispersion (PWD) was significantly higher in classic MVP patients than in non-classic MVP patients.
  • PWD correlated positively with P wave duration, leaflet displacement, leaflet thickness, and left atrial diameter; leaflet thickness and displacement were independent predictors of increased PWD.

Conclusions:

  • Classic MVP patients demonstrate prolonged PWD values.
  • Elevated PWD in classic MVP suggests potential autonomic dysfunction and an increased risk for atrial arrhythmias.
Keywords:
Autonomic dysfunctionP wave dispersionmitral valve prolapse

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