Possible Predictors of Adverse Outcomes in Children with Acute Viral Hepatitis in a Low-Middle-Income Country
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View abstract on PubMed
Summary
This summary is machine-generated.Hepatitis A is the primary cause of acute viral hepatitis in children, with most cases recovering well. However, certain clinical and biochemical indicators may predict mortality, particularly in boys.
Area Of Science
- Pediatrics
- Hepatology
- Infectious Diseases
Background
- Acute viral hepatitis (AVH) is a significant concern in pediatric populations.
- Understanding the etiological spectrum and clinical outcomes of AVH is crucial for effective management.
Purpose Of The Study
- To investigate the causes, clinical presentations, and biochemical profiles of children with AVH.
- To identify predictors of mortality in pediatric AVH cases.
Main Methods
- A study involving 158 children (≤18 years) with AVH symptoms was conducted.
- Data collection included comprehensive history, physical examination, investigations, and outcome monitoring.
- Statistical analysis was performed using SPSS version 25.
Main Results
- Hepatitis A was the most frequent cause (76.6%) of AVH.
- The overall mortality rate was 6.3%, with higher rates observed in boys.
- Splenomegaly, ascites, bleeding, encephalopathy, acute liver failure, elevated bilirubin, prolonged PT/INR, and low albumin were associated with mortality.
Conclusions
- Hepatitis A virus is the leading cause of AVH in children, generally with a good prognosis.
- Specific clinical signs and biochemical markers can predict mortality in pediatric AVH.
- Early recognition of these predictors is vital for timely intervention and improved outcomes.
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