Related Experiment Video
Updated: Jan 11, 2026
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Trajectory subgroups and influencing factors of nutrition-related risk in older NSCLC patients undergoing
Jufeng Zhang1, Mingjie Gu1, Zhimei Chen1
1The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital), Nanjing, LA, 210029, China.
Background:
Malnutrition in older non-small cell lung cancer (NSCLC) patients undergoing chemotherapy correlates with poor outcomes. While nutritional risk is dynamic, longitudinal trajectory patterns remain uncharacterized in this population.
Objectives:
The present study aimed to explore the trajectory subgroups and influencing factors of nutrition-related risk over time among older adults with advanced NSCLC undergoing first-line chemotherapy.
Design:
A retrospective longitudinal study.
Methods:
In total, 353 patients aged > 60 years who were diagnosed with advanced NSCLC and received at least six cycles of chemotherapy at a single tertiary oncology center between January 2022 and June 2024 were enrolled in this study. Nutrition-related risk was assessed with Geriatric Nutritional Risk Index (GNRI). The trajectory subgroups of nutrition-related risk over time were analyzed using the latent class growth modeling (LCGM). An unordered multi-class logistic regression analysis was performed to find the influencing factors of different trajectories.
Results:
The average age of 353 patients was (68.2 ± 6.1) years, among which 272 (77.1%) were male. According to LCGM, the three categories of nutrition-related risk trajectories were identified, which were stable low risk group (n = 188, 53.3%), improving moderate risk group (n = 124, 35.1%), and persistent high to moderate risk group (n = 41, 11.6%). Unordered multi-class logistic regression analysis showed that age, smoking status, and hypertension were associated with the trajectory categories of nutrition-related risks.
Conclusions:
Nutrition risk follows distinct trajectories during chemotherapy cycles, with 11.6% of older adults with NSCLC exhibiting sustained high vulnerability. Older age, smoking history, and hypertension are key predictors of this adverse trajectory. Assessment of these readily available and easily accessible clinical factors at treatment initiation may enable early identification of high-risk patients for targeted nutritional interventions.
Related Concept Videos
02:59Cancer Prevention
Some...
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:21Cancer Survival Analysis
01:27Nursing Ethical Principles II
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...