Shifting trends in influenza and rising HBoV cases: a comparative analysis over 3-winter seasons
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.The COVID-19 pandemic shifted pediatric respiratory virus patterns, increasing human bocavirus 1 (HBoV1) prevalence while decreasing influenza. HBoV1 alone doesn't cause severe illness, but co-infections increase pediatric acute respiratory tract infection (ARTI) morbidity.
Area Of Science
- Pediatric infectious diseases
- Epidemiology of viral infections
- Public health and virology
Background
- Acute respiratory tract infections (ARTIs) are a significant cause of pediatric hospitalizations.
- The COVID-19 pandemic altered the circulation of respiratory viruses, including influenza and human bocavirus 1 (HBoV1).
Purpose Of The Study
- To investigate the pandemic's impact on HBoV1 prevalence in pediatric ARTIs.
- To analyze the clinical implications of HBoV1 during the post-pandemic period.
Main Methods
- A retrospective cohort study analyzed pediatric emergency department data from pre-pandemic (2017-2019) and post-pandemic (2022-2024) winter seasons.
- Multiplex PCR identified respiratory viruses in nasopharyngeal swabs.
- Clinical data, hospitalization rates, and disease severity were evaluated.
Main Results
- HBoV1 prevalence significantly increased post-pandemic (9.5% to 20.8%), while influenza A/B declined.
- Co-infections decreased overall but were strongly associated with HBoV1.
- Severe illness was linked to co-infections (aOR: 7.3) and young age (≤1 year, aOR: 2.6).
Conclusions
- The post-pandemic era shows increased HBoV1 and decreased influenza in pediatric ARTIs.
- HBoV1 is not associated with severe disease independently; co-infections, especially with RSV, increase morbidity.
- Findings emphasize the need for ongoing viral surveillance and adaptive clinical strategies for pediatric respiratory infections.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
Predicting Outbreaks
Predictive analytics, a branch of statistics, uses historical data, algorithmic models, and...
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Viral Recombination Can Create New Diseases
Some diseases can infect multiple species. For example, pigs can be infected by some human and...
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
Overview
Vaccination is the administration of antigenic material from pathogens to confer immunity against a specific microorganism. Vaccination primes the immune system to recognize and mount an immune response faster and more effectively if the real pathogen is encountered. Vaccinations are one of the most efficient ways to protect both individual humans and the general public from disease. A growing anti-vaccination skepticism risks the successes of vaccination programs that helped reduce...
Before understanding the types and patterns of fever, it is essential to know its phases.
• The first stage is the onset/invasion phase, during which the body temperature rises. It might be a sudden or gradual process.
• The second stage is the steady phase, during which the body temperature has reached its maximum and remains constant at a high level.
• The third stage is the defervescence or decline phase, during which the elevated temperature returns to...