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Early alternative splicing signatures and RBP networks in MASLD progression to cirrhosis

Li Chen1, Wei Ma1, Yaoqing Hu2

  • 1Department of Traditional Chinese Medicine, Wuhan Integrated TCM and Western Medicine Hospital, Wuhan, China.

BMC Medical Genomics
|November 19, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Alternative splicingCirrhosis progressionImmune microenvironmentMetabolic dysfunction-associated steatotic liver disease (MASLD)RNA-Binding proteins (RBPs)

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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