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Related Experiment Video

Updated: Jan 11, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Cannabis use and suicide: a case-control study based on integrative data analysis.

Qiongyu Shi1, Guohua Li2,3

  • 1Department of Biostatistics, Columbia University Mailman School of Public Health, 722 West 168th St, New York, NY, 10032, USA.

Journal of Cannabis Research
|November 19, 2025
PubMed
Summary

Cannabis use significantly increases suicide risk by 83%, independent of alcohol. Policymakers should consider this elevated risk when evaluating cannabis legalization, as cannabis use is a significant suicide risk factor.

Keywords:
CannabisCase-controlData fusionIntegrative data analysisMultiple imputationSuicide.

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Area of Science:

  • Public Health
  • Epidemiology
  • Substance Use Research

Background:

  • Cannabis use is linked to depression and suicidal behaviors.
  • The direct association between cannabis use and suicide death requires further investigation due to data limitations.

Purpose of the Study:

  • To assess the association between cannabis use and suicide death.
  • Utilizing a case-control design and integrative data analysis.

Main Methods:

  • Cases: Suicide decedents (aged 16+ from NVDRS). Controls: NSDUH respondents.
  • Data fusion of NSDUH and NRS data, including toxicological testing, to improve accuracy of cannabis use assessment.
  • Weighted multivariable logistic regression to estimate odds ratios (aORs) for suicide associated with cannabis and alcohol use.

Main Results:

  • Cannabis use was detected in 17.1% of suicide cases versus 7.2% of controls.
  • Cannabis use was associated with an 83% increased odds of suicide (aOR=1.83).
  • Alcohol use showed a 20-fold increased odds of suicide (aOR=20.53); male sex, White race, age 35-49, and lower education also increased odds.

Conclusions:

  • Cannabis use is an independent risk factor for suicide.
  • Findings highlight the need to consider suicide risk in cannabis legalization policies.
  • Public health strategies should address the link between cannabis use and suicide.