Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

312
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
312
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

290
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
290
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

298
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
298
Tissue Transplantation01:24

Tissue Transplantation

875
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
875
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

845
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
845

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dihydropyridine Calcium Channel Blocker Therapy and Risk of CKD Progression in Type 2 Diabetes Treated With Renin Angiotensin System Inhibitors and SGLT2 Inhibitors: A Real-World Retrospective Cohort Study.

Kidney medicine·2026
Same author

Safe and Early Primary Closure of Open Abdomen in Pediatric Liver Transplantation Using a Doppler-Guided Tension Relief Strategy and Enhanced Wound Environment.

Journal of transplantation·2026
Same author

Surgical repair of paraesophageal hernia resolves unexplained iron deficiency anemia in the vast majority of patients: a propensity-matched multicenter study.

Surgical endoscopy·2026
Same author

Early pregnancy is characterized by a significant decrease in the diversity of the oral microbiome and strong associations with lifestyle and conception method.

Journal of oral microbiology·2026
Same author

Hyperphosphataemia, but not hypercalcaemia, predicts cardiovascular risk after kidney transplantation.

Clinical kidney journal·2026
Same author

GRIMM-II: A Two-Stage Real-Time Algorithm for Nine-Locus HLA Imputation and Matching with Up to Three Mismatches.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 11, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.6K

Soft kidney allocation improves HLA matching and maintains allocation order.

Sapir Israeli1, Eytan Mor2, Maya Mor Cohen2

  • 1Department of Mathematics, Bar-Ilan University, Ramat Gan, Israel.

Communications Medicine
|November 19, 2025
PubMed
Summary

A new soft allocation strategy significantly improves Human Leukocyte Antigen (HLA) matching in kidney transplants. This method enhances graft survival and reduces antibody risks without disrupting transplant equity.

More Related Videos

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.5K
A Modified Surgical Technique for Kidney Transplantation in Mice
10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

7.0K

Related Experiment Videos

Last Updated: Jan 11, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.6K
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.5K
A Modified Surgical Technique for Kidney Transplantation in Mice
10:38

A Modified Surgical Technique for Kidney Transplantation in Mice

Published on: July 22, 2022

7.0K

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Public health policy

Background:

  • Current kidney allocation systems prioritize equity but often neglect Human Leukocyte Antigen (HLA) matching, potentially shortening graft lifespan and increasing donor-specific antibody (DSA) risks.
  • This can lead to poorer long-term transplant outcomes and increased immunological complications for recipients.

Purpose of the Study:

  • To introduce and evaluate a "soft allocation" strategy designed to enhance HLA matching in kidney transplantation.
  • The goal is to improve graft survival and reduce DSA formation while maintaining minimal disruption to existing allocation queues and equity principles.

Main Methods:

  • The soft allocation strategy involves offering a kidney to the best HLA match within a defined group (K) of top-ranked potential recipients, rather than the first in line.
  • This method considers directed-living, non-directed-living, and deceased donors, preserving essential compatibility factors like blood type and age.
  • It also offers protection for recipients with rare HLA types.

Main Results:

  • Analysis of 95,250 deceased donor transplants in the US showed an increase in HLA-A&B&DR match scores from 1.45 to 1.77.
  • In Israel, soft allocation improved match scores in deceased donor transplants (from 2.33 to 2.54) and non-directed living donor transplants (from 1.34 to 2.03).
  • Related donor-recipient pairs undergoing crossover transplants also demonstrated a three-fold improvement in HLA matching without negatively impacting recipient matches.

Conclusions:

  • Soft allocation effectively enhances HLA matching for both unrelated and related kidney transplants within established allocation rules.
  • This strategy offers significant immunological benefits with minimal disruption to allocation order and equity.
  • Future research aims to apply this approach to sensitized donations, further optimizing transplant outcomes.