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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Assessment of cardiac function by speckle tracking echocardiography in children with osteogenesis imperfecta
Saeed Elseedy1, Shimaa Elnemr2, Shaimaa Badreldeen2
1Ministry of Health and Population, Tanta, Egypt.
Insights
Children with osteogenesis imperfecta (OI) exhibit subclinical cardiac dysfunction, including impaired left and right ventricular function. These abnormalities correlate with disease severity, underscoring the need for regular echocardiographic monitoring.
Area of Science:
- Pediatric Cardiology
- Genetic Disorders
- Echocardiography
Background:
- Osteogenesis imperfecta (OI) is a genetic disorder affecting collagen 1, leading to skeletal fragility and potential extra-skeletal complications.
- Cardiovascular involvement, including aortic dilatation, is recognized in adult OI patients.
- Pediatric assessment of ventricular function in OI using advanced echocardiography remains understudied.
Purpose of the Study:
- To evaluate subclinical left ventricular (LV) and right ventricular (RV) dysfunction in children with OI.
- To utilize two-dimensional speckle tracking echocardiography (2D-STE) for detailed cardiac function assessment.
- To correlate cardiac abnormalities with the clinical severity of osteogenesis imperfecta.
Main Methods:
- A cross-sectional study involving 30 children with OI and 30 age- and sex-matched healthy controls.
- Conventional echocardiography, tissue Doppler imaging, and 2D-STE were performed on all participants.
- Clinical severity of OI was assessed and correlated with echocardiographic parameters.
Main Results:
- Children with OI showed significantly lower height, weight, and hemoglobin compared to controls.
- Larger aortic diameter, left atrial diameter, LV dimensions, right ventricular diameter, and mean pulmonary artery diameter were observed in the OI group.
- Reduced LV and RV systolic function (2D-GLS, S wave) and diastolic function (E/é) were significantly lower in children with OI.
- Clinical severity correlated positively with cardiac chamber dimensions and negatively with ventricular strain parameters.
Conclusions:
- Children with osteogenesis imperfecta present with subclinical left and right ventricular systolic and diastolic dysfunction.
- These cardiac abnormalities are associated with the clinical severity of OI.
- Regular echocardiographic follow-up is recommended for pediatric patients with OI to monitor cardiac health.
Background:
We aimed to assess the subclinical cardiac dysfunction in children with osteogenesis imperfecta (OI) using two-dimensional speckle tracking echocardiography (2D-STE).
Methods:
This cross-sectional study was carried out on 30 children with OI and 30 healthy children of matched age and sex. All children underwent conventional and tissue Doppler echocardiography, as well as 2D-STE.
Results:
Height, weight, and hemoglobin were significantly lower in the patient group than in the control group. Aorta (AO), left atrial diameter (LAD), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), right ventricular diameter (RVD), and mean pulmonary artery (MPA) were significantly larger in the patient group compared to the control group. Mitral E/é, LV S, LV 2D-global longitudinal strain (2D-GLS), TAPSE, RV S, and RV 2D-GLS were significantly lower in the patient group than the control group. There was a significant positive correlation between the clinical severity of disease and (AO, LAD, LVESD, LVEDD, MPA, and RVD). There was a significant negative correlation between the severity of disease and LV 2D-GLS, RV é/á, and RV 2D-GLS.
Conclusion:
Children with OI have subclinical LV and RV systolic and diastolic dysfunction, and these abnormalities were correlated with the clinical severity of the disease.
Impact:
Osteogenesis imperfecta (OI) is an inherited disease of abnormal collagen 1 with extra-skeletal involvement, such as cardiovascular complications. Aortic dilatation and valvular dysfunction have been reported in adult patients with OI. However, right and left ventricular function assessment using two-dimensional speckle tracking echocardiography has not been studied in pediatrics before. We found that children with OI have subclinical LV and RV systolic and diastolic dysfunction, and these abnormalities are correlated with the clinical severity of the disease. Regular echocardiographic follow-up is recommended for these patients.
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