Understanding Peelle's Pertinent Puzzle bias in generalized least squares regression through eigenspectrum analysis

Noah A W Walton1,2, William N Fritsch3, Amanda M Lewis4,3

  • 1Los Alamos National Laboratory, Los Alamos, 87545, NM, USA. nwalton@lanl.gov.

Scientific Reports
|November 19, 2025
PubMed
Summary

Peele's Pertinent Puzzle (PPP) bias in generalized least squares (GLS) regression arises from specific data covariance matrix (DCM) correlations. A new framework uses eigenspectrum analysis to understand and generalize this bias, offering solutions for experimental data analysis.

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