Association between in vitro fertilization and severe neonatal morbidity

Area of Science:

• Reproductive Medicine
• Neonatal Health
• Perinatal Outcomes

Background:

• In vitro fertilization (IVF) is a common assisted reproductive technology.
• Understanding neonatal outcomes associated with IVF is crucial for clinical practice.
• Previous research has suggested potential links between IVF and adverse neonatal events.

Purpose of the Study:

• To investigate the association between in vitro fertilization (IVF) and severe neonatal morbidity.
• To explore the role of donor oocytes in neonatal outcomes.
• To compare respiratory versus non-respiratory severe neonatal morbidity in IVF and non-IVF cohorts.
• To assess antenatal steroid administration rates between conception groups.

Main Methods:

• Retrospective cohort study of singleton deliveries (2019-2023).
• Primary outcome: severe neonatal morbidity (composite measure including diagnoses and procedures).
• Secondary outcome: antepartum steroid administration.
• Statistical analysis: multivariable logistic regression, odds ratios (ORs) with 95% confidence intervals (CIs).

Main Results:

• A total of 46,761 pregnancies were analyzed, with 2,327 conceived via IVF.
• Severe neonatal morbidity occurred in 10.5% of IVF infants versus 6.9% of non-IVF infants.
• IVF conception was associated with a significantly increased risk of severe neonatal morbidity (aOR 1.42, 95% CI: 1.23-1.66).

Conclusions:

• Infants conceived via IVF demonstrate a higher likelihood of experiencing severe neonatal morbidity.
• Further research is warranted to elucidate the underlying mechanisms.
• Findings can inform counseling for prospective parents and optimize neonatal care strategies.