Related Experiment Video

Updated: Jan 11, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma

Yan Li1, Songsong Wang2,3, Yilong Lin2

  • 1Hubei University of Chinese Medicine, Wuhan, 430060, Hubei, China.

Discover Oncology
|November 19, 2025
PubMed
Abstract

Insights

Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) is upregulated in kidney cancer, promoting tumor growth and invasion. High CDKN2A expression correlates with drug sensitivity, suggesting it as a potential therapeutic target for clear cell renal cell carcinoma (ccRCC).

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer, with rising incidence.
  • The role of Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) in ccRCC pathogenesis requires further investigation.

Purpose of the Study:

  • To elucidate the function of CDKN2A in ccRCC.
  • To explore CDKN2A's correlation with clinical features, immune infiltration, and drug sensitivity in ccRCC.

Main Methods:

  • Analysis of TCGA and GEO database ccRCC data.
  • Assessment of CDKN2A expression, clinical correlations, immune cell infiltration, and drug sensitivity.
  • Experimental validation of CDKN2A's role in ccRCC cell behavior.

Main Results:

  • CDKN2A expression is elevated in ccRCC tissues and linked to poorer prognosis.
  • High CDKN2A expression correlates with sensitivity to MAPK pathway-targeting drugs.
  • CDKN2A promotes ccRCC cell proliferation, migration, and invasion via the MAPK pathway.

Conclusions:

  • CDKN2A exhibits an oncogenic role in ccRCC.
  • CDKN2A represents a potential therapeutic target for ccRCC treatment.
Keywords:
BioinformaticsCDKN2AClear cell renal cell carcinomaMAPK signaling pathwayTherapeutic target

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