Lactucaindicas a-C: three newly identified compounds from lactuca indica L. that inhibit NO production
Nguyen Thi Ha1,2, Do Thi Trang3, Pham Hai Yen3
1Drug, Cometic and Food Quality Control Center, Ha Tinh, Vietnam.
Natural Product Research
|November 19, 2025
Abstract:
Three undescribed compounds (named indicalatucas A-C), including two lignans (1 and 2) and an abscisic alcohol glycoside (3), together with six known neolignans (4-9), were extracted from the leaves of Lactuca indica L. Their structures were elucidated using HRESIMS, ECD, and NMR spectroscopy. Among them, compound 1 significaltly inhibited NO production in LPS-activated RAW 264.7 cells (IC50: 15.8 µM).
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