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The Relationship Between Aortic Tissue Sirtuin 1 Levels and Type A Aortic Dissections and Ascending Aortic Aneurysms
Mehmet Rum1, Bulend Ketenci1, Fatih Kizilyel1
1University of Health Sciences Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital Department of Cardiovascular Surgery Istanbul Turkiye Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic Cardiac and Vascular Surgery Hospital, University of Health Sciences, Istanbul, Turkiye.
Brazilian Journal of Cardiovascular Surgery
|November 19, 2025
Summary
Ascending aortic aneurysms and dissections show elevated sirtuin 1 (SIRT1) tissue levels. Atherosclerotic diseases and hypertension are linked to decreased SIRT1, impacting cardiovascular health.
Area of Science:
- Cardiovascular Surgery
- Molecular Biology
- Pathology
Background:
- Type A aortic dissections carry high mortality.
- Ascending aortic aneurysms are significant precursors to dissection.
- This study investigates sirtuin 1 (SIRT1) in human ascending aorta.
Purpose of the Study:
- To elucidate the relationship between ascending aortic pathologies and SIRT1 protein.
- To compare SIRT1 levels in ascending aortic aneurysm, type A aortic dissection, and control groups.
Main Methods:
- Case-control study design.
- Analysis of aortic tissues and demographic data from 46 patients.
- Comparison of SIRT1 protein levels across surgical groups and disease states.
Main Results:
- SIRT1 protein levels were highest in ascending aortic aneurysm, followed by dissection, and lowest in controls (P=0.014).
- Low SIRT1 levels correlated with coronary artery disease (P=0.001), peripheral artery disease (P=0.008), and hypertension (P=0.023).
Conclusions:
- Type A aortic dissection is associated with elevated SIRT1 tissue levels.
- Systemic atherosclerotic diseases (CAD, PAD) and hypertension are linked to decreased SIRT1.
- SIRT1 may play a complex role in ascending aortic pathologies and associated comorbidities.
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