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Biointerface Behavior of Layered Double Hydroxides: Dispersibility and Toxicity Assessment Using Experimental and

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Magnesium-aluminum layered double hydroxide (Mg-Al LDH) nanosheets show stable dispersions and low cellular toxicity at environmentally relevant concentrations. This research supports their safe application across various fields.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Toxicology

Background:

  • Layered double hydroxide (LDH) nanosheets are versatile nanomaterials with broad applications.
  • Understanding their biological and environmental interactions is crucial for safe and sustainable use.
  • Mg-Al LDH nanosheets require thorough investigation of their biointerface behavior.

Purpose of the Study:

  • To synthesize and characterize Mg-Al LDH nanosheets.
  • To evaluate the dispersibility, environmental stability, and biological interactions of Mg-Al LDH.
  • To assess the safety profile of Mg-Al LDH nanosheets using integrated experimental and computational methods.

Main Methods:

  • Synthesis and characterization of Mg-Al LDH nanosheets.
  • Dispersibility tests in various biological and environmental media.
  • Cellular uptake, viability, ROS generation, DNA damage, apoptosis, and mitochondrial permeability assays in HepG2 and HL60 cells.
  • Computational docking studies with apoptotic signaling proteins.

Main Results:

  • Mg-Al LDH nanosheets exhibited stable dispersions in relevant media for up to 72 hours.
  • Cellular uptake of Mg and Al was dose- and time-dependent; cytotoxicity observed at high concentrations (mg/L).
  • No significant ROS generation or DNA damage at low concentrations (ng-μg/L); mitochondrial alterations occurred at higher doses without inducing apoptosis.
  • Computational analysis revealed weak interactions with apoptotic proteins.
  • Environmentally relevant concentrations (ng-μg/L) showed no significant adverse effects on cellular parameters.

Conclusions:

  • Mg-Al LDH nanosheets demonstrate concentration-dependent biosafety.
  • Favorable dispersion properties and intrinsic characteristics contribute to a low-hazard biological profile.
  • Findings support the safe application of Mg-Al LDH nanosheets, particularly at environmentally relevant concentrations.