Tracking Systemic Inflammation in Allergic Rhinitis with Immune-Inflammation Markers

Area of Science:

• Immunology
• Clinical Medicine
• Biomarker Discovery

Background:

• Allergic rhinitis (AR) is characterized by nasal inflammation but also involves systemic inflammatory responses.
• Evaluating systemic inflammation biomarkers is crucial for understanding and managing AR.

Purpose of the Study:

• To assess the diagnostic and monitoring utility of systemic inflammation biomarkers in AR.
• To investigate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and serum SCUBE levels in AR patients.

Main Methods:

• A prospective study involving 88 AR patients and 50 healthy controls.
• AR patients received nasal corticosteroid (NCS) therapy.
• Assessed symptom severity (VAS, CARAT) and measured NLR, PLR, SII, PIV, and SCUBE levels pre- and post-treatment.

Main Results:

• AR patients showed significantly higher PLR, SII, and PIV compared to controls.
• Nasal corticosteroid therapy led to significant clinical improvement and decreased NLR, PLR, and SII levels.
• PIV, SII, and PLR demonstrated potential as diagnostic biomarkers for AR.

Conclusions:

• PLR, SII, and PIV are elevated in AR, indicating a significant systemic inflammatory component.
• NLR, PLR, and SII levels decrease with effective AR treatment.
• SII and PIV are promising, accessible biomarkers for assessing and monitoring inflammation in allergic rhinitis.