Related Experiment Video
Updated: Jun 19, 2026
07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
3.4K
Development of the advised protocol for OCT study terminology and elements anterior segment OCT extension reporting
Ameenat Lola Solebo1,2,3, Marcus Ang4,5, Alice Bellchambers1,2,6
1Population, Policy and Practice Department, UCL GOS Institute of Child Health, London, United Kingdom.
Plos One
|November 19, 2025
Summary
Standardized reporting for anterior segment optical coherence tomography (AS-OCT) studies is crucial for reproducibility. The APOSTEL-AS checklist will improve data consistency and clinical application of AS-OCT findings.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Anterior segment optical coherence tomography (AS-OCT) shows promise for diagnosing and monitoring eye conditions like glaucoma and uveitis.
- Lack of standardized reporting hinders reproducibility and interoperability of AS-OCT studies.
- Existing guidelines need extension to specifically address AS-OCT applications.
Purpose of the Study:
- To develop reporting guidelines for AS-OCT studies.
- To extend the Advised Protocol for OCT Study Terminology and Elements (APOSTEL) for AS-OCT.
- To enhance standardization, interoperability, and reproducibility in AS-OCT research.
Main Methods:
- A staged consensus process following EQUATOR Network guidance.
- Systematic scoping review to identify reporting items and form Delphi group.
- Delphi methodology with an 80% consensus threshold and steering committee review.
- Piloting of the APOSTEL-AS guideline before final dissemination.
Main Results:
- Development of the APOSTEL-AS checklist.
- Inclusion of minimum and recommended reporting items for AS-OCT studies.
- Establishment of a consensus nomenclature for AS-OCT ocular structure representation.
Conclusions:
- The APOSTEL-AS checklist will standardize AS-OCT study reporting.
- Improved reporting will enhance research reproducibility and data interoperability.
- This will accelerate the translation of AS-OCT knowledge into clinical practice.
More Related Videos
Related Concept Videos
01:56Ethics in Research
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
01:10Computed Tomography
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:27Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...