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Neurological manifestations associated with SARS-CoV-2 infection in pediatric patients: a systematic review

Bruna de Jesus Santos1, Emerson André Negrão do Nascimento1, Ludmila Oliveira Dos Reis1

  • 1Universidade Federal do Pará, Belém, PA, Brazil.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|November 19, 2025
PubMed

Insights

Neurological symptoms such as seizures, headache, and altered consciousness are common in children and adolescents with COVID-19. This systematic review highlights these key findings in pediatric patients.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • The neurological impact of SARS-CoV-2 (the virus causing COVID-19) in pediatric populations remains an area requiring comprehensive understanding.
  • Existing research often has gaps in age range coverage, necessitating a focused review on individuals aged zero to 19 years.

Conclusions:

  • Neurological manifestations are relatively common in pediatric COVID-19 cases, presenting a spectrum from mild symptoms to severe complications.
  • The findings emphasize the need for continued research to elucidate the underlying mechanisms of these neurological sequelae in children and adolescents.
Abstract

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