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Left Ventricular Diastolic Dysfunction Increases the Risk of Medium-term Mortality in Patients with Cirrhotic Ascites

Sheng-Hao Li1, Lu Zhang1, Hong-Juan Li2

  • 1School of Public Health, School of Public Health, Dali University, no. 2, Hongsheng Road, Dali Town, Dali Bai Autonomous Prefecture, Dali City 671000, Yunnan Province, P.R. China.

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|November 19, 2025
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is an independent risk factor for 1-year mortality in patients with cirrhotic ascites. Early detection of LVDD can help predict prognosis, especially in patients without hepatic malignancy.

Area of Science:

  • Cardiology
  • Hepatology
  • Medical Prognostics

Background:

  • Cirrhotic ascites is a common complication of advanced liver disease.
  • Left ventricular diastolic dysfunction (LVDD) is increasingly recognized in patients with liver cirrhosis.
  • The prognostic implications of LVDD in cirrhotic ascites patients require further elucidation.

Purpose of the Study:

  • To investigate the association between left ventricular diastolic dysfunction (LVDD) and medium-term mortality in patients with cirrhotic ascites.
  • To identify LVDD as an independent risk factor for 1-year mortality in this population.
  • To compare the predictive value of LVDD with established prognostic scores.

Main Methods:

  • Retrospective study including 194 patients with cirrhotic ascites.
  • Echocardiography used to categorize patients into LVDD and non-LVDD groups.
  • Lasso, univariate, and multivariate Cox regression analyses for risk factor identification.
  • Kaplan-Meier curves and time-dependent ROC curves for survival analysis.

Main Results:

  • Left ventricular diastolic dysfunction (LVDD) was identified in 47.4% of patients.
  • LVDD was an independent predictor of 1-year mortality (Hazard Ratio = 2.109, P = 0.003).
  • LVDD demonstrated comparable predictive performance to CTP and MELD scores for 1-year mortality, particularly in patients without hepatic malignancy.

Conclusions:

  • Left ventricular diastolic dysfunction (LVDD) significantly increases the risk of 1-year mortality in patients with cirrhotic ascites.
  • LVDD serves as a valuable prognostic marker, especially in cirrhotic ascites patients without hepatic malignancy.
  • Routine echocardiographic assessment for LVDD may aid in risk stratification and management of cirrhotic ascites.
Abstract

Keywords:
cirrhotic ascitesclinic risk factorhepato-cardiac disorderleft ventricular diastolic dysfunctionmedium-term poor clinical outcome

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