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Related Concept Videos

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
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A Multicomponent Intervention to Improve Maternal Infection Outcomes.

David Lissauer1,2, Luis Gadama3, Catriona Waitt1,4

  • 1Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool Women's Hospital, Liverpool, United Kingdom.

The New England Journal of Medicine
|November 19, 2025
PubMed
Summary
This summary is machine-generated.

The Active Prevention and Treatment of Maternal Sepsis (APT-Sepsis) program significantly reduced maternal deaths and severe illness. This multicomponent intervention improved sepsis prevention and management in low-resource settings.

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Area of Science:

  • Global Health
  • Obstetrics & Gynecology
  • Infectious Diseases

Background:

  • Maternal infection and sepsis are leading causes of maternal mortality globally, especially in low- and middle-income countries.
  • Delayed detection and inconsistent implementation of evidence-based practices contribute to preventable maternal deaths.

Purpose of the Study:

  • To evaluate the effectiveness of the Active Prevention and Treatment of Maternal Sepsis (APT-Sepsis) program.
  • To reduce infection-related maternal death, near-miss events, and severe illness.

Main Methods:

  • A cluster-randomized trial involving 59 health facilities in Malawi and Uganda.
  • Intervention included adherence to hand hygiene, evidence-based infection management, and early sepsis detection using the FAST-M bundle.
  • Control group received usual care and guideline dissemination.

Main Results:

  • The APT-Sepsis program resulted in a 32% reduction in the composite outcome (risk ratio, 0.68; P<0.001).
  • Primary outcome events occurred in 1.4% of the intervention group versus 1.9% in the usual-care group.
  • The intervention's benefits were consistent across countries and facility types and sustained over time.

Conclusions:

  • The APT-Sepsis program significantly lowered the risk of infection-related maternal morbidity and mortality compared to usual care.
  • This multicomponent intervention is effective in improving maternal outcomes in resource-limited settings.