Related Experiment Video
Updated: Jan 11, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
A simple five-factor risk model for predicting new-onset diabetes after distal pancreatectomy
Wei-Hsun Lu1, Ting-Kai Liao1, Ping-Jui Su2
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Taiwan; Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan.
Background:
New-onset diabetes mellitus (NODM) following distal pancreatectomy (DP) significantly impacts long-term quality of life. This study developed a prediction model for post-DP NODM.
Methods:
Retrospective analysis of 159 patients undergoing DP for benign/low-grade malignant lesions (2014-2023). Cox regression identified risk factors incorporated into a scoring system.
Results:
Among 130 non-diabetic patients, 26.9 % developed NODM (median 10 months). Five independent predictors: prediabetes (HR 11.02), concomitant splenectomy (HR 2.45), age ≥65 (HR 2.03), BMI ≥25 (HR 1.96), neck/proximal tumor (HR 1.50). The risk scoring system (0-10 points) stratified patients into low-risk (0-2 points), intermediate-risk (3-5 points), and high-risk (6-10 points) categories with significantly different cumulative incidence of NODM at 5 years (4.4 %, 27.9 %, and 87.5 %, respectively). AUC exceeded 0.85 across timepoints.
Conclusions:
This simple model enables accurate risk stratification for post-DP NODM, facilitating personalized counseling and tailored surveillance.
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Chronic Pancreatitis II: Collaborative Care
Assessment:

