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Retrospective SPECT-MR fusion: a great problem-solving tool
S M A Bukhari1, A Singh2, N AlArab1
1University Hospitals Cleveland Medical Center, USA.
Clinical Radiology
|November 19, 2025
Summary
Image fusion combines anatomical and functional imaging data for improved diagnostics. This review guides SPECT-MR fusion, highlighting its clinical benefits and future potential.
Area of Science:
- Radiology
- Medical Imaging
- Image Processing
Background:
- Different imaging modalities offer complementary anatomical, functional, and physiological data.
- Integrating these diverse image types can create a comprehensive view, improving diagnostic accuracy.
- Image fusion techniques are crucial for combining multimodal datasets effectively.
Purpose of the Study:
- To review the principles and methods of retrospective image fusion.
- To provide a practical guide for performing image fusion, specifically SPECT-MR fusion.
- To explore the clinical applications, advantages, and future directions of SPECT-MR fusion.
Main Methods:
- Review of fundamental principles of image fusion.
- Step-by-step procedural guide for image fusion using specialized software.
- Exploration of clinical case studies and comparative analyses of SPECT-MR fusion.
Main Results:
- Image fusion enables synergistic representation of anatomical and functional data.
- SPECT-MR fusion offers enhanced diagnostic insights compared to standalone imaging.
- The review details the technical alignment and co-registration of multimodal imaging data.
Conclusions:
- Retrospective image fusion is a powerful tool for enhancing diagnostic accuracy.
- SPECT-MR fusion presents significant clinical advantages and promising future advancements.
- This technique facilitates better clinical decision-making through integrated imaging insights.

