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From visualization to prediction: Dissecting metabolic heterogeneity with DDRTree.

Yonghua Yu1, Hong Lin1

  • 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.

Cell Reports. Medicine
|November 19, 2025
PubMed
Summary

The discriminative dimensionality reduction tree (DDRTree) framework helps identify distinct patient subtypes in type 2 diabetes and obesity. This approach reveals metabolic heterogeneity for better risk profiling.

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