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Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
Published on: October 25, 2019
Modulation of host functions by bacterial serine/threonine protein kinase effector proteins
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Abstract:
Protein phosphorylation, one of the most ubiquitous and evolutionarily conserved posttranslational modifications, serves as a master regulator of cellular signaling networks. In host-pathogen interactions, bacterial subversion of phosphorylation-dependent signaling pathways has emerged as a pivotal mechanism of microbial pathogenesis. Notably, recent advances in eukaryotic-like serine/threonine protein kinase effector proteins have profoundly advanced our understanding of molecular pathogenesis through their ability to hijack host cell signaling. In this review, we will summarize the sophisticated strategies by which bacterial serine/threonine protein kinase effectors manipulate host phosphorylation networks to enhance virulence and promote infection.
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