Working Against the Clock: Depression and Hormonal Imbalance in Shift-Working Men.
Niki Parikh1, Amelia Oppenheimer2, Juliet McNamara Alexander2
1UT Southwestern Medical Center, Dallas, TX.
Urology
|November 19, 2025
Summary
Low testosterone and shift work are linked to higher depression scores in men. Addressing these factors is crucial for improving men's mental health and well-being.
Area of Science:
- Endocrinology
- Men's Health
- Psychiatry
Background:
- Hypogonadism symptoms are common in men presenting to urology clinics.
- Depression and shift work are potential contributing factors to hypogonadal symptoms.
Purpose of the Study:
- To investigate the relationship between testosterone levels, depressive symptoms, and shift work in men with hypogonadism symptoms.
Main Methods:
- Retrospective chart review and survey of 766 men.
- Utilized Patient Health Questionnaire-9 (PHQ-9) and Shift Work Sleep Disorder (SWSD) Questionnaire.
- Analyzed serum testosterone levels and medication history.
Main Results:
- A significant inverse relationship between testosterone and PHQ-9 scores was observed.
- Men at low risk for SWSD had lower PHQ-9 scores and less suicidal ideation.
- Differences in PHQ-9 scores were noted between eugonadal and hypogonadal men not on medication.
Conclusions:
- Testosterone levels, shift work, and depression are significantly associated in men with hypogonadal symptoms.
- Routine depression screening is vital for hypogonadal men, especially those in shift work.
- Counseling should be considered for these patient groups.
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