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Related Experiment Video

Updated: Jun 29, 2026

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MYB Alterations in Angiocentric Gliomas.

Isabela Peña Pino1, A Yohan Alexander1, Sanjay Dhawan1

  • 1Department of Neurosurgery and Center for Skull Base and Pituitary Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|November 19, 2025
PubMed
Summary
This summary is machine-generated.

MYB alterations are common in angiocentric glioma, with MYB::QKI fusions being the most frequent. This review details their clinical features and highlights MYB fusions as key drivers in neuro-oncologic diseases, suggesting therapeutic potential.

Keywords:
MYBangiocentric gliomaoncogeneoncologytumor

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Area of Science:

  • Neuro-oncology
  • Molecular Pathology
  • Genetics

Background:

  • Angiocentric glioma is a rare brain tumor.
  • MYB gene alterations are increasingly recognized as key drivers in various cancers.
  • Understanding MYB alterations in angiocentric glioma is crucial for diagnosis and treatment.

Purpose of the Study:

  • To systematically review MYB alterations in angiocentric glioma.
  • To define the clinical characteristics associated with these alterations.
  • To present a novel MYB mutation in an angiocentric glioma case.

Main Methods:

  • Systematic literature review following PRISMA guidelines.
  • Searched PubMed and Web of Science (2010-October 2024).
  • Included 14 studies with 114 patients; analyzed one novel case.

Main Results:

  • The mean patient age was 10.3 years, with 60% males.
  • MYB::QKI fusion was the most common alteration (68%).
  • Other MYB alterations and cerebral cortex location were frequently observed.

Conclusions:

  • This study characterizes angiocentric glioma demographics, location, and MYB fusion patterns.
  • MYB fusions are important in neuro-oncologic diseases, including adenoid cystic carcinomas.
  • Further research into MYB fusions as prognostic markers and therapeutic targets is warranted.