Related Experiment Video
Updated: Jun 29, 2026
08:35
A Human Glioblastoma Organotypic Slice Culture Model for Study of Tumor Cell Migration and Patient-specific Effects of Anti-Invasive Drugs
Published on: July 20, 2017
13.6K
MYB Alterations in Angiocentric Gliomas
Isabela Peña Pino1, A Yohan Alexander1, Sanjay Dhawan1
1Department of Neurosurgery and Center for Skull Base and Pituitary Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Summary
MYB alterations are common in angiocentric glioma, with MYB::QKI fusions being the most frequent. This review details their clinical features and highlights MYB fusions as key drivers in neuro-oncologic diseases, suggesting therapeutic potential.
Area of Science:
- Neuro-oncology
- Molecular Pathology
- Genetics
Background:
- Angiocentric glioma is a rare brain tumor.
- MYB gene alterations are increasingly recognized as key drivers in various cancers.
- Understanding MYB alterations in angiocentric glioma is crucial for diagnosis and treatment.
Purpose of the Study:
- To systematically review MYB alterations in angiocentric glioma.
- To define the clinical characteristics associated with these alterations.
- To present a novel MYB mutation in an angiocentric glioma case.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Searched PubMed and Web of Science (2010-October 2024).
- Included 14 studies with 114 patients; analyzed one novel case.
Main Results:
- The mean patient age was 10.3 years, with 60% males.
- MYB::QKI fusion was the most common alteration (68%).
- Other MYB alterations and cerebral cortex location were frequently observed.
Conclusions:
- This study characterizes angiocentric glioma demographics, location, and MYB fusion patterns.
- MYB fusions are important in neuro-oncologic diseases, including adenoid cystic carcinomas.
- Further research into MYB fusions as prognostic markers and therapeutic targets is warranted.
Related Concept Videos
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...