Primary Gastric Alveolar Rhabdomyosarcoma

Primary gastric alveolar rhabdomyosarcoma (RMS) is an extremely rare condition. We report a case of a 32-year-old man who presented with abdominal distension and anorexia. Imaging revealed a gastric mass with peritoneal dissemination and vertebral metastasis. Endoscopy revealed a large, ulcerative lesion. Histopathology revealed small round cells in an alveolar pattern that were positive for desmin and myogenin. Despite the initiation of multimodal therapy, the patient developed septic shock and died 10 days after treatment. This case highlights the aggressive nature of primary gastric alveolar RMS and emphasizes the importance of integrated diagnostic approaches, including histopathological, immunohistochemical, and molecular analyses, for its accurate diagnosis and appropriate management.