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Updated: Jan 10, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
Published on: January 13, 2022
General Approach to Weakness
Woodrow Sams1, Nimra Hassan1, William J Meurer2
1Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Abstract:
Weakness is a challenging and broad chief complaint in emergency medicine, necessitating rapid and accurate differentiation among numerous etiologies. Effective diagnosis involves recognizing symptoms of central and peripheral neurologic disorders, neuromuscular junction diseases, nutritional deficiencies, and toxin exposures. Prompt identification and intervention in conditions such as Guillain-Barré syndrome, transverse myelitis, botulism, and nutritional deficiencies are crucial. Despite vaccines reducing cases of polio, tetanus, and diphtheria, vigilance remains essential due to their potential resurgence. This article emphasizes a systematic evaluation, critical diagnostic challenges, management pitfalls, and future directions for improving patient outcomes.
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