Related Experiment Video
Updated: Jan 10, 2026
12:47
Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
19.3K
Among patients undergoing induction who reach active phase, does prolonged latent phase matter?
Kira A Bromwich1,2, Rebecca F Hamm2,3, Lisa D Levine2,3
1Department of OB/GYN, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Summary
A prolonged latent phase during labor induction increases the risk of cesarean delivery (CD) and maternal/neonatal complications. However, most patients still achieve a vaginal birth, though with higher morbidity.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Labor and Delivery Management
Background:
- Induction of labor (IOL) is common for term gestations with unfavorable cervices.
- The latent phase of labor can be prolonged, raising concerns about outcomes.
- Understanding risks associated with a prolonged latent phase is crucial for clinical decision-making.
Purpose of the Study:
- To evaluate the association between a prolonged latent phase and the risk of cesarean delivery (CD) in patients undergoing labor induction.
- To assess the impact of a prolonged latent phase on maternal and neonatal morbidity.
Main Methods:
- Secondary analysis of a prospective cohort study (2018-2022) including term singleton gestations undergoing IOL.
- Defined prolonged latent phase as <6 cm dilation after ≥12 hours with ruptured membranes and oxytocin, prior to active labor (≥6 cm).
- Used multivariable logistic regression to analyze primary (CD) and secondary outcomes (labor arrest, morbidity), stratified by parity.
Main Results:
- A prolonged latent phase occurred in 6.3% of patients reaching active labor.
- Patients with a prolonged latent phase had a higher CD rate (25.2% vs. 9.9%) and increased risk of clinical chorioamnionitis and composite maternal/neonatal morbidities.
- The increased CD risk was significant after adjustment and primarily observed in nulliparous patients.
Conclusions:
- A prolonged latent phase in induced labor is linked to higher rates of cesarean delivery and maternal/neonatal morbidity, particularly in nulliparous individuals.
- Despite increased risks, the majority of patients with a prolonged latent phase achieve vaginal delivery.
- Clinical monitoring and management should consider the potential for increased complications associated with a prolonged latent phase.
Related Concept Videos
01:28Pulmonary Tuberculosis V
530
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
530
01:22Stages of General Anesthesia
1.4K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.4K
01:26Stages of Infection
64.8K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.8K
01:26Psychosis: Goals of Pharmacotherapy
449
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
449
01:11Clinical Trials: Overview
4.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.5K
01:20Desensitization and Tachyphylaxis
3.0K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.0K