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Tracing cancer progression through interpretable spatial multi-omics

Ada Junquera1, Anniina Färkkilä2

  • 1Research Program in Systems Oncology Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Trends in Cancer
|November 19, 2025
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Keywords:
compartment biologymulti-omics integrationspatial proteomicsspatial transcriptomics