Related Experiment Video
Updated: Jan 10, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.6K
Bladder Preservation After Neoadjuvant Therapy for Muscle-invasive Bladder Cancer in the Current Era: Myth and
Emanuele Crupi1, Andrea Necchi2, Ashish M Kamat3
1Department of Genitourinary Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
European Urology Focus
|November 19, 2025
Summary
Bladder preservation after neoadjuvant therapy for muscle-invasive bladder cancer is becoming a disciplined approach. Growing evidence and biomarker strategies are advancing bladder-sparing treatments towards successful bladder-intact cures.
Area of Science:
- Oncology
- Urology
Background:
- Muscle-invasive bladder cancer (MIBC) treatment traditionally involves radical cystectomy.
- Bladder preservation strategies are emerging as an alternative to cystectomy.
- Neoadjuvant therapy followed by bladder preservation is under investigation for MIBC.
Purpose of the Study:
- To evaluate the evolving paradigm of bladder preservation in muscle-invasive bladder cancer.
- To highlight the transition from empirical approaches to evidence-based strategies.
- To discuss the role of neoadjuvant therapy and biomarkers in bladder-sparing treatment.
Main Methods:
- Review of growing prospective data on bladder preservation.
- Analysis of consensus standardization efforts.
- Integration of biomarker-driven strategies in treatment planning.
Main Results:
- Bladder preservation is moving from an investigational to a maturing evidence paradigm.
- Prospective data and standardization are supporting bladder-sparing approaches.
- Biomarker-driven strategies are enhancing the precision of these treatments.
Conclusions:
- Bladder preservation following neoadjuvant therapy for MIBC is a promising, evidence-maturing strategy.
- While awaiting randomized validation, current data support a disciplined approach to bladder sparing.
- The goal is to achieve bladder-intact cure for patients with muscle-invasive bladder cancer.
Related Concept Videos
01:30Urinary Tract Calculi III: Medical Management
185
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
185
01:25Urinary Tract Calculi VI: Surgical Management
343
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
343
01:17Urinary Tract Infection IV: Nursing Management
407
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
407
01:26Kidney Transplant II: Surgical Procedure
290
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
290
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
1.1K
Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
1.1K
01:23Urinary Bladder
3.0K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.0K