Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

786
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
786
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

514
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
514
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

449
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
449
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

468
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
468
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

454
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
454

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis.

Biomarkers in neuropsychiatry·2026
Same author

Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.

Communications biology·2026
Same author

Behavioral Inhibition Network Predicts Alcohol Use in Men and Stress in Women.

Journal of studies on alcohol and drugs·2026
Same author

Brain regions with gestational age differences mediate cognition in adolescents born very premature.

Communications biology·2026
Same author

Family-Level Brain Pattern Similarities and Their Clinical Significance in Young Offspring of Individuals With Psychotic Disorders.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026

Related Experiment Video

Updated: Jan 10, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K

Spatiotemporal complexity in the psychotic brain.

Qiang Li1, Jingyu Liu2,3, Godfrey D Pearlson4

  • 1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA 30303, USA. qli27@gsu.edu.

Molecular Psychiatry
|November 19, 2025
PubMed
Summary

Psychotic disorders disrupt brain complexity, leading to increased randomness and instability in brain networks. This study introduces "brainquake" to describe these profound alterations in information integration and organization.

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.4K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.2K

Related Experiment Videos

Last Updated: Jan 10, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.4K
Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

13.2K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Complexity Science

Background:

  • Psychotic disorders like schizophrenia and bipolar disorder present diagnostic challenges.
  • Resting-state fMRI spatiotemporal complexity measures offer insights into brain activity irregularities.
  • Traditional pairwise correlation analyses have limitations in capturing global brain connectivity.

Purpose of the Study:

  • To explore higher-order interactions and multiscale intrinsic connectivity networks (ICNs) in the psychotic brain using information-theoretic metrics.
  • To investigate disruptions in brain network connectivity, specifically the balance between redundant and synergistic information.
  • To identify specific brain regions and networks affected by psychosis-related alterations.

Main Methods:

  • Utilized information-theoretic metrics to capture global brain connectivity, moving beyond pairwise correlations.
  • Estimated brain network connectivity using redundancy and synergy measures.
  • Analyzed higher-order topological functional connectivity in resting-state fMRI data.

Main Results:

  • The psychotic brain exhibits increased spatial and temporal randomness.
  • A disruption in the balance of redundant and synergistic information, termed "brainquake," was observed, indicating network instability.
  • Profound disruptions in information integration were found across cortical and subcortical ICNs.
  • Sensorimotor, visual, temporal, default mode, fronto-parietal networks, hippocampus, and amygdala showed significant alterations.

Conclusions:

  • Psychosis is associated with a fundamental alteration in the brain's complexity and organizational states.
  • The "brainquake" phenomenon highlights the instability and disorganization of brain networks in psychosis.
  • Findings underscore the severe impact of psychotic states on multiscale critical brain networks.