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Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural

Jeet Bahadur Singh1,2,3, Bartomeu Perelló-Amorós4, Jenny Schneeberg5

  • 1Leibniz Institute for Neurobiology (LIN), 39118, Magdeburg, Germany.

EMBO Reports
|November 19, 2025
PubMed
Summary

Neuronal activity triggers extracellular matrix (ECM) degradation in the brain, a process vital for structural synaptic plasticity and the formation of new dendritic connections.

Keywords:
ADAMTSAggrecanDendritic SpinesPerineuronal NetsProprotein Convertase

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