Related Experiment Video
Updated: Jan 10, 2026
Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
A scoping review of symptom clusters in adult leukemia patients undergoing chemotherapy
Shujia Liu1, Lei Wang, Jiating Wang
1Department of Hematology, Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China.
Background:
Patients with leukemia undergoing chemotherapy frequently present with a cluster of co-occurring symptoms, which exacerbate both physical and mental burdens and may worsen prognosis. A comprehensive review of the types, characteristics, and research status of these symptom clusters is thus necessary to inform and improve symptom management strategies.
Methods:
A systematic search was conducted in 8 databases, including PubMed, Embase, CINAHL, Web of Science, CNKI, Wanfang Database, VIP Database, and China Biomedical Literature Database, for relevant studies on symptom clusters in leukemia patients during chemotherapy. The retrieval period spanned from the inception of the databases until June 28, 2024.
Results:
Nine studies identified 11 symptom clusters concluding skin-related, oral-related, self-image impairment, gastrointestinal, nervous system-related, psychological, energy deficiency, adverse reaction, pain-related, nutritional, and disease behavior symptom clusters. Notably, the gastrointestinal and psychological symptom clusters were the most prevalent.
Conclusion:
Leukemia patients undergoing chemotherapy commonly experience multiple symptom clusters, yet there are substantial variations in the internal composition of these clusters. Future research should focus on exploring specific symptom assessment tools for leukemia patients and integrating multiple advanced analysis methods, such as machine learning, to improve the accuracy of symptom cluster identification and support the formulation of targeted management strategies.
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:56Treatment Resistant Cancers
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...