Recent Advances and Patents in Manufacturing Technologies Used for the Preparation of Solid Dispersion

Solid Dispersions have become an important tool for improving the bioavailability and solubility of drugs that are poorly water soluble in water, especially those classified as BCS class II and IV. Due to advanced manufacturing techniques and patented innovations, the applicability of solid dispersions has increased. A detailed literature search was conducted using databases such as Google Scholar, PubMed, Google Patents and Science Direct. This review paper analyzes the modern manufacturing techniques and patented innovations used for the preparation of solid dispersion. Modern manufacturing techniques such as solvent evaporation, spray drying, hot melt extrusion, electrospinning and supercritical fluid methods have significantly enhanced the consistency, safety, stability and scalability of solid dispersions. Additionally, patented innovations such as MeltrexTM, KinetiSol, etc., have broadened their potential use in pharmaceutical formulations. Long term stability, recrystallization and process scalability continue to be major obstacles despite these developments. Continued innovations in manufacturing techniques and stability enhancement strategies are important for a safe and stable formulation.