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Nuclear DAB2IP regulates DNA replication initiation through activating PLK1-mediated HBO1 phosphorylation

Zeng-Fu Shang1, Lan Yu2, Ciara Newman1

  • 1Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas TX 75390, United States.

Nucleic Acids Research
|November 20, 2025
PubMed
Summary

Disabled homolog 2 interacting protein (DAB2IP) promotes DNA replication initiation and maintains genome stability. Its interaction with HBO1 and phosphorylation by CDK1 are crucial for DNA replication and cellular homeostasis.

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