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Gastrin signaling in cardiovascular pathophysiology: From molecular crosstalk to clinical implications

Chunmei Xu1,2, Zhuxin Li1,2, Yongchun Zeng1,2,3

  • 1Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|November 20, 2025
PubMed

Insights

Gastrin, a gastrointestinal hormone, is linked to cardiovascular diseases like coronary heart disease and hypertension. Elevated gastrin levels may increase the risk of heart conditions and offer cardioprotective effects.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology
  • Gastroenterology

Background:

  • Gastrin is a gastrointestinal hormone regulating gastric acid and intestinal nutrition.
  • Gastrin is implicated in cardiovascular conditions such as coronary heart disease, ischemia-reperfusion injury, and hypertension.

Purpose of the Study:

  • To systematically review the association between gastrin and cardiovascular diseases.
  • To elucidate the mechanisms underlying gastrin's cardioprotective effects and its role in hypertension.

Main Methods:

  • Systematic literature retrieval from major scientific databases (PubMed, Web of Science, CNKI).
  • Analysis of existing studies on gastrin's physiological roles and clinical associations.

Main Results:

  • High serum gastrin levels correlate with increased coronary heart disease risk and myocardial infarction.
  • Gastrin administration improves myocardial contractility via CCKBR and protects against ischemia-reperfusion injury through STAT3 signaling.
  • Gastrin may influence blood pressure via central nervous system or direct vasodilation.

Conclusions:

  • Gastrin is significantly associated with cardiovascular diseases, potentially acting as a risk factor or protective agent.
  • Gastrin exerts cardioprotective effects and plays a role in regulating blood pressure.

Keywords:
CCKBRGastrincoronary heart diseasegastrointestinal hormonehypertension

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