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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Selection Of The Most Appropriate Radiation Treatment Modality For Children's Cancers: A Paediatric Radiation Oncology Society (pros) Position Paper On The Ethical Utilization Of Proton Therapy.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Selection Of The Most Appropriate Radiation Treatment Modality For Children's Cancers: A Paediatric Radiation Oncology Society (pros) Position Paper On The Ethical Utilization Of Proton Therapy.

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Selection of the Most Appropriate Radiation Treatment Modality for Children's Cancers: A Paediatric Radiation Oncology Society (PROS) Position Paper on the Ethical Utilization of Proton Therapy.

Natia Esiashvili1, Daniel J Indelicato2, Anita Mahajan3

  • 1Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia, USA.

Pediatric Blood & Cancer
|November 20, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
access to carefinancial toxicityhealth equitypediatric radiation oncology

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Proton beam therapy (PBT) offers benefits for pediatric cancer but has ethical and access concerns. High-quality photon therapy is an effective alternative, emphasizing equitable, evidence-based radiotherapy decisions for children globally.

Area of Science:

  • Pediatric Oncology
  • Radiation Oncology
  • Medical Ethics

Background:

  • Proton beam therapy (PBT) provides dosimetric advantages in pediatric radiotherapy, reducing healthy tissue radiation exposure.
  • Widespread PBT implementation faces ethical, logistical, and equity challenges, particularly in resource-limited settings.

Purpose of the Study:

  • To review the clinical rationale for selecting radiotherapy modalities in children.
  • To focus on the ethical utilization of PBT in pediatric cancer care.
  • To address disparities in access and inform decision-making.

Main Methods:

  • A position paper by the Paediatric Radiation Oncology Society (PROS) synthesizing evidence on PBT and photon therapies.
  • Exploration of access disparities, the role of local oncologists, and industry influence on family choices.
proton therapy
radiotherapy ethics

Main Results:

  • PBT offers clinical benefits for specific pediatric cancers, but IMRT/VMAT are effective and accessible alternatives.
  • PBT referral processes can be complex, causing delays; travel and financial burdens worsen disparities.
  • Local pediatric radiation oncologists play a crucial role in family counseling; balanced communication is vital.

Conclusions:

  • An ethical, equitable, and evidence-informed approach to pediatric radiotherapy selection is advocated.
  • PBT should be used when clinically indicated and accessible without delaying care.
  • Investment in radiation therapy infrastructure, education, research, and responsible messaging is crucial for global pediatric cancer outcomes.