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Subicular Astrocytes Govern Seizure-Impaired Fear Memory.

Yuying Shao1,2, Jing Xi1, Yuhao Sun1

  • 1Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 20, 2025
PubMed
Summary
This summary is machine-generated.

Subicular astrocytes modulate fear memory. Seizure activity disrupts this by overactivating astrocytes, leading to memory deficits, but targeting these cells may offer therapeutic benefits for seizure-related memory disorders.

Keywords:
astrocytesepilepsyfear memoryseizuresubiculum

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Epilepsy Research

Background:

  • Cognitive impairment is a common comorbidity of epileptic seizures.
  • The subiculum, a hippocampal region, is implicated in both seizures and cognition.
  • Astrocytes, glial cells in the brain, play roles in neuronal function and plasticity.

Purpose of the Study:

  • To investigate the role of subicular astrocytes in seizure-associated fear memory deficits.
  • To elucidate the mechanisms by which astrocytes contribute to cognitive impairment during seizures.

Main Methods:

  • Studied astrocyte activation in the subiculum during fear memory learning and seizure activity.
  • Manipulated astrocyte calcium signaling and Gq pathway in subicular astrocytes.
  • Investigated the role of adenosine signaling via A1 receptors.

Main Results:

  • Subicular astrocytes are activated during fear memory learning and hyperactivated by seizures.
  • Suppression of astrocyte calcium signaling rescued seizure-induced memory deficits.
  • Astrocyte Gq pathway activation mimicked cognitive impairment.
  • Seizure-induced astrocyte dysfunction involves Ca2+-dependent adenosine release via A1 receptors.

Conclusions:

  • Subicular astrocytes are critical mediators of seizure-induced fear memory deficits.
  • Astrocyte dysregulation, involving adenosine signaling, disrupts neural circuit homeostasis during seizures.
  • Targeting subicular astrocytes offers a potential therapeutic strategy for seizure-related memory disorders.