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Updated: Jan 10, 2026
07:40
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
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[Avoidable adverse effects : 10 drug combinations to watch closely].
Fabiano Casso1, Ayoub Larabi2, Virginie Moulin1
1Département de médecine interne, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Revue Medicale Suisse
|November 20, 2025
Summary
This review highlights 10 common drug combinations, like SSRIs-tramadol, that pose significant risks for patients on multiple medications. Understanding these drug interactions improves prescribing safety and patient care.
Area of Science:
- Internal Medicine
- Clinical Pharmacology
- Pharmacovigilance
Background:
- Drug interactions are a common cause of adverse events in internal medicine.
- Polymedication increases the risk of potentially harmful drug combinations.
Purpose of the Study:
- To review 10 frequent drug combinations with significant clinical risk.
- To provide guidance on managing drug interactions for safer prescribing.
Main Methods:
- Literature review of common drug interactions.
- Analysis of mechanisms, clinical consequences, and management strategies.
Main Results:
- Identified 10 high-risk drug combinations, including SSRIs-tramadol, statins-CYP3A4 inhibitors, nitrates-PDE5 inhibitors, and lithium-NSAIDs/diuretics.
- Detailed the pharmacological basis and clinical impact of each interaction.
Conclusions:
- Awareness of these drug interactions is crucial for prescribers.
- Implementing practical recommendations can enhance patient safety and care quality.
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