Related Experiment Video
Updated: Jan 10, 2026
11:15
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.6K
Extracellular Vesicles in Sarcoma: Implications for Tumor Progression and Therapy
Yue Wang1,2, Shaozhi Gao3, Geng Zhang3
1Central Laboratory, Affiliated Hospital of Putian University, School of Basic Medicine, Putian University, Putian, Fujian Province, 351100, People's Republic of China.
International Journal of Nanomedicine
|November 20, 2025
Summary
Extracellular vesicles (EVs) are key players in sarcoma progression, driving tumor growth and spread. Targeting these EVs offers new hope for sarcoma diagnosis and treatment.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Sarcoma is a challenging cancer due to its aggressive nature and treatment resistance.
- Extracellular vesicles (EVs) mediate intercellular communication within the tumor microenvironment, influencing sarcoma progression.
Purpose of the Study:
- To review the diverse roles of EVs in sarcoma pathogenesis.
- To explore EV-based strategies for sarcoma diagnosis, prognosis, drug delivery, and immunotherapy.
Main Methods:
- Comprehensive literature review of recent research on EVs in sarcoma.
- Analysis of subtype-specific EV mechanisms in osteosarcoma and liposarcoma.
- Evaluation of current and emerging EV-based therapeutic and diagnostic applications.
Main Results:
- EVs promote sarcoma progression by facilitating epithelial-mesenchymal transition (EMT), angiogenesis, and immune evasion.
- EVs show potential as non-invasive biomarkers for early sarcoma detection and prognosis.
- Engineered EVs can be utilized for targeted drug delivery and immunotherapy in sarcoma.
Conclusions:
- EVs are critical mediators in sarcoma development and progression.
- EVs represent a promising avenue for developing novel diagnostic and therapeutic strategies for sarcoma.
- Further research into EV-based precision medicine is essential for improving sarcoma management.
Related Concept Videos
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
02:30Metastasis
6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
01:36Overview of Exosomes
3.5K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.5K
01:38Intralumenal Vesicles and Multivesicular Bodies
4.7K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
4.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.1K