Application of composite layered repair system using titanium mesh, bone cement and vacuum sealing drainage for chest...

To evaluate the therapeutic efficacy of a composite layered repair system utilizing titanium mesh (TM), bone cement (BC) and vacuum sealing drainage (VSD) for chest wall defect reconstruction, providing a reliable theoretical foundation and practical guidance for clinical chest wall trauma management.

A thoracic defect model (≥6 × 6 cm²) was established in 22 adult goat and then divided into the TM + BC + VSD, TM + BC and TM + VSD groups. The survival status, activity status, wound recovery, vital signs, blood routine, arterial blood gas and inflammatory factor levels of the three goat groups were monitored and compared after the operation.

All groups demonstrated comparable survival rates and periods with satisfactory defect repair outcomes. The PaO₂ at multiple time points after surgery in the TM + BC + VSD group were higher than those in the TM + BC and TM + VSD groups, while the activity status score, WBC and levels of PaCO₂, IL-2, IL-6, IL-10, IL-17 and TNF-α were lower than those in the TM + BC and TM + VSD groups. The SpO₂, hemoglobin and erythrocyte were higher than those in the TM + VSD group, and the wound healing score, heart rate was lower than that in the TM + VSD group.

The composite laminated repair system constructed by TM, BC and VSD can increase the survival rate after chest wall defect repair, promote functional recovery, improve oxygenation and reduce inflammatory responses, and has potential clinical application value.