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Updated: Jan 10, 2026

Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions
Published on: October 5, 2019
Synthesis, characterization, biomolecular interaction, potent aqueous singlet oxygen generation and NADH
Bhumika Joshi1, Rishav Das1, Rinku Chakrabarty2
1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology Vellore 632014 Tamil Nadu India priyankar.paira@vit.ac.in mshivashankar@vit.ac.in.
Abstract:
Cyclometalated iridium complexes have been a great choice for PDT agents over the last few decades. Herein, we endeavoured to introduce a newly synthesized Ir(iii) complex [LIr], focusing on its photophysical properties, DNA interactions, and catalytic potential. DNA-binding studies indicated a combination of binding interactions with notable affinity (K = 1.04 × 105 M-1) and a high Stern-Volmer quenching constant (K SV = 7.35 × 109 M-1), suggesting strong DNA association, while UV-visible spectroscopy confirmed robust MLCT transitions. The complex efficiently generated singlet oxygen with a quantum yield of 0.0613, highlighting its potential for photodynamic therapy. Additionally, it demonstrated moderate catalytic activity in NADH oxidation, with a turnover number (TON) of 4.22 and a turnover frequency (TOF) of 8.46 h-1, both enhanced under visible light, thereby establishing complex [LIr] as a promising future candidate for DNA-targeted therapies and photoactivated catalysis.
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