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Updated: May 12, 2026

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
Exploring wine-processing: a distinctive classic technique in TCM
Jinbo Li1, Chao Sun2, Ajiao Hou1
1Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education No. 24 Heping Road, Xiangfang Harbin 150040 China hxk_yl@163.com jianghai_777@126.com.
Abstract:
Wine-processing represents a distinctive technique in Traditional Chinese medicine (TCM) preparation. Refined through millennia of practice, it embodies ancient wisdom in modulating medicinal properties. This method utilizes interactions between wine and herbs to enhance targeted delivery, moderate cold/bitter properties, amplify therapeutic effects, and reduce toxicity. Its clinical significance remains paramount. We systematically analyzed literature from scientific databases (Baidu Scholar, CNKI, Google Scholar, PubMed, ScienceDirect, Web of Science, SciFinder), historical texts, and the 2025 Chinese Pharmacopoeia. Graphical abstracts were generated using the Generic Diagramming Platform (GDP, https://www.BioGDP.com) to identify research gaps and future priorities. Evidence confirmed wine-processing improves channel tropism, enhances kidney/liver tonification, and increases bioactive compound solubility. Nevertheless, significant challenges hinder its modernization. Future research should prioritize process parameter optimization, quality-marker discovery, and multi-omics studies to scientifically elucidate efficacy-toxicity modulation mechanisms and advance clinical translation of this traditional technique.
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